Both the Olympic and the Titanic registered Liverpool as their home port. The offices of the White Star Line as well as Cunard were in Liverpool and up until the introduction of the Olympic most British oceanliners for both Cunard and White Star, such as the Lusitania and Mauretania, sailed out of Liverpool followed by a port of call in Ireland. However, the Olympic class liners were to sail out of the port of Southampton on England's southern coast. Southampton had many advantages to Liverpool, the first being its closer proximity to London. In addition Southampton, being on England's southern coast, allowed ships to easily cross the English Channel and make a port of call in northern France, usually at the port of Cherbourg. This allowed British ships to pick up clientele from continental Europe before recrossing the channel and picking up passengers in southern Ireland. The Southampton-Cherbourg-New York run would become so popular that most British oceanliners began using the port after World War I. Though out of respect for Liverpool ships would continue to be registered there, a practice that would last until the early 1960s. The RMS Queen Elizabeth 2 would be one of the first ships to be registered in Southampton when introduced into service by Cunard in 1969.
Titanic's maiden voyage was intended to be the first of many cross-Atlantic journeys between Southampton in England, Cherbourg in France, Queenstown in Ireland and New York in the United States, returning via Plymouth in England on the eastbound leg. Indeed, her entire schedule of voyages through to December 1912 still exists. The White Star Line intended to operate three ships on that route: Titanic, Olympic and the smaller RMS Oceanic. Each would sail once every three weeks from Southampton and New York, usually leaving at noon each Wednesday from Southampton and each Saturday from New York, thus enabling the White Star Line to offer weekly sailings in each direction. Special trains were scheduled from London and Paris to convey passengers to Southampton and Cherbourg respectively. The deep-water dock at Southampton, then known as the "White Star Dock" had been specially constructed to accommodate the new Olympic-class liners, and had opened in 1911.



Crew



Titanic had around 885 crew members on board for her maiden voyage. Like other vessels of her time, she did not have a permanent crew, and the vast majority of crew members were casual workers who only came aboard the ship a few hours before she sailed from Southampton. The process of signing up recruits had begun on 23 March and some had been sent to Belfast, where they served as a skeleton crew during Titanic's sea trials and passage to England at the start of April.

Captain Edward John Smith, the most senior of the White Star Line's captains, was transferred from Olympic to take command of Titanic. Henry Tingle Wilde also came across from Olympic to take the post of Chief Mate. Titanic's previously designated Chief Mate and First Officer, William McMaster Murdoch and Charles Lightoller, were bumped down to the ranks of First and Second Officer respectively. The original Second Officer, David Blair, was dropped altogether.
Titanic's crew were divided into three principal departments: Deck, with 66 crew; Engine, with 325; and Victualling, with 494. The vast majority of the crew were thus not seamen, but were either engineers, firemen or stokers, responsible for looking after the engines, or stewards and galley staff, responsible for the passengers. Of these, over 97% were male; just 23 of the crew were female, mainly stewardesses. The rest represented a great variety of professions—bakers, chefs, butchers, fishmongers, dishwashers, stewards, gymnasium instructors, laundrymen, waiters, bed-makers, cleaners and even a printer, who produced a daily newspaper for passengers called the Atlantic Daily Bulletin with the latest news received by the ship's wireless operators.
Most of the crew signed on in Southampton on 6 April; in all, 699 of the crew came from there, and 40 percent were natives of the town. A few specialist staff were self-employed or were subcontractors. These included the five postal clerks, who worked for the Royal Mail and the United States Post Office Department, the staff of the First Class A La Carte Restaurant and the Café Parisien, the radio operators (who were employed by Marconi) and the eight musicians, who were employed by an agency and travelled as second-class passengers. Crew pay varied greatly, from Captain Smith's £105 a month (equivalent to £7,704 today) to the £3 10s (£257 today) that stewardesses earned. The lower-paid victualling staff could, however, supplement their wages substantially through tips from passengers.



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Passengers



Titanic's passengers numbered around 1,317 people: 324 in First Class, 284 in Second Class and 709 in Third Class. 869 (66%) were male and 447 (34%) female. There were 107 children aboard, the largest number of which were in Third Class The ship was considerably under capacity on her maiden voyage, as she could accommodate 2,566 passengers—1,034 First Class, 510 Second Class and 1,022 Third Class.

Usually, a high prestige vessel like Titanic could expect to be fully booked on its maiden voyage. However, a national coal strike in the U.K. had caused considerable disruption to shipping schedules in the spring of 1912, causing many crossings to be cancelled. Many would-be passengers chose to postpone their travel plans until the strike was over. The strike had finished a few days before Titanic sailed; however, that was too late to have much of an effect. Titanic was able to sail on the scheduled date only because coal was transferred from other vessels which were tied up at Southampton, such as City of New York and Oceanic as well as coal Olympic had brought back from a previous voyage to New York and which had been stored at the White Star Dock.
Some of the most prominent people of the day booked a passage aboard Titanic, travelling in First Class. Among them were the American millionaire John Jacob Astor IV and his wife Madeleine Force Astor, industrialist Benjamin Guggenheim, Macy's owner Isidor Straus and his wife Ida, Denver millionairess Margaret "Molly" Brown, Sir Cosmo Duff Gordon and his wife, couturière Lucy (Lady Duff-Gordon), cricketer and businessman John Borland Thayer with his wife Marian together with their son Jack, the Countess of Rothes, author and socialite Helen Churchill Candee, journalist and social reformer William Thomas Stead, author Jacques Futrelle with his wife May, and silent film actress Dorothy Gibson, among others. Titanic's owner J. P. Morgan was scheduled to travel on the maiden voyage, but cancelled at the last minute. Also aboard the ship were the White Star Line's managing director J. Bruce Ismay and Titanic's designer Thomas Andrews, who was on board to observe any problems and assess the general performance of the new ship.
The exact number of people aboard is not known as not all of those who had booked tickets made it to the ship; about fifty people cancelled for various reasons, and not all of those who boarded stayed aboard for the entire journey.
Fares aboard Titanic varied enormously in cost. Third Class fares from London, Southampton or Queenstown cost £7 5s (equivalent to £532 today) while the cheapest First Class fares cost £23 (£1,688 today).[82] The most expensive First Class suites were to have cost up to £870 in high season (£63,837 today).





Departure and westbound journey



On Wednesday 10 April 1912 the Titanic's maiden voyage began. Following the embarkation of the crew the passengers began arriving from 9.30 am when the London and South Western Railway's boat train from London Waterloo station reached Southampton Terminus railway station on the quayside, right alongside Titanic's berth. The large number of Third Class passengers meant that they were the first to board, with First and Second Class passengers following up to within an hour of departure. Stewards showed them to their cabins and First Class passengers were personally greeted by Captain Smith on boarding. Third Class passengers were inspected for ailments and physical impairments that might lead to them being refused entry to the United States—not a prospect that the White Star Line wished to see, as it would have to carry them back across the Atlantic. 922 passengers were recorded as having embarked Titanic at Southampton. Further passengers were picked up at Cherbourg and Queenstown.

The maiden voyage began on time at noon. An accident was narrowly averted only a few minutes later as Titanic passed the moored liners SS City of New York and Oceanic. Her huge displacement caused both of the smaller ships to be lifted by a bulge of water, then dropped into a trough. New York's mooring cables could not take the sudden strain and snapped, swinging her around stern-first towards Titanic. A nearby tugboat, Vulcan, came to the rescue by taking New York under tow and Captain Smith ordered Titanic's engines to be put "full astern". The two ships avoided a collision by a matter of about 4 feet (1.2 m). The incident delayed Titanic's departure for about an hour while the drifting New York was brought under control.

After making it safely through the complex tides and channels of Southampton Water and the Solent, Titanic headed out into the English Channel. She headed for the French port of Cherbourg, a journey of 77 nautical miles (89 mi; 143 km). The weather was windy, very fine but cold and overcast. Because Cherbourg lacked docking facilities for a ship the size of Titanic, tenders had to be used to transfer passengers from shore to ship. The White Star Line operated two at Cherbourg, the SS Traffic and the SS Nomadic. Both had been designed specifically as tenders for the Olympic-class liners and were launched shortly after Titanic  (Nomadic is today the only White Star Line ship still afloat.) Six hours after Titanic left Southampton, she arrived at Cherbourg and was met by the tenders. 274 more passengers boarded Titanic and 24 left aboard the tenders to be conveyed to shore. The process was completed within only 90 minutes and at 8 pm Titanic weighed anchor and left for Queenstown with the weather continuing cold and windy.

At 11.30 am on Thursday 11 April, Titanic arrived at Queenstown Harbour on the south coast of Ireland. It was a partly cloudy but relatively warm day with a brisk wind. Again, the dock facilities were not suitable for a ship of her size, and tenders were used to bring passengers aboard. 113 Third Class and seven Second Class passengers came aboard, while seven passengers left. Among the departures was Father Francis Browne, a Jesuit trainee, who was a keen photographer and took many photographs aboard Titanic, including the last-ever known photograph of the ship. A decidedly unofficial departure was that of a crew member, stoker John Coffey, a native of Queenstown who sneaked off the ship by hiding under mail bags being transported to shore.[109] Titanic weighed anchor for the last time at 1.30 pm and departed on her westward journey across the Atlantic.​

After leaving Queenstown Titanic followed the Irish coast as far as Fastnet Rock, a distance of some 55 nautical miles (63 mi; 102 km). From there she travelled 1,620 nautical miles (1,860 mi; 3,000 km) along a Great Circle route across the North Atlantic to reach a spot in the ocean known as "the corner" south-east of Newfoundland, where westbound steamers carried out a change of course. Titanic sailed only a few hours past the corner on a rhumb line leg of 1,023 nautical miles (1,177 mi; 1,895 km) to Nantucket Shoals Light when she made her fatal rendezvous with an iceberg. The final leg of the journey would have been 193 nautical miles (222 mi; 357 km) to Ambrose Light and finally to New York Harbor.​

The first three days of the voyage from Queenstown passed without incident. From 11 April to local apparent noon the next day, Titanic covered 484 nautical miles (557 mi; 896 km); the following day, 519 nautical miles (597 mi; 961 km); and by noon on the final day of her voyage, 546 nautical miles (628 mi; 1,011 km). From then until the time of her sinking she travelled another 258 nautical miles (297 mi; 478 km), averaging about 21 knots (24 mph; 39 km/h). The weather cleared as she left Ireland under cloudy skies with a headwind. Temperatures remained fairly mild on Saturday 13 April, but the following day Titanic crossed a cold weather front with strong winds and waves of up to 8 feet (2.4 m). These died down as the day progressed until, by the evening of Sunday 14 April, it became clear, calm and very cold.
Titanic received a series of warnings from other ships of drifting ice in the area of the Grand Banks of Newfoundland. Nonetheless the ship continued to steam at full speed, which was standard practice at the time. It was generally believed that ice posed little danger to large vessels and Captain Smith himself had declared that he could not "imagine any condition which would cause a ship to founder. Modern shipbuilding has gone beyond that.



Sinking



At 11.40 pm on 14 April (ship's time), lookout Frederick Fleet spotted an iceberg immediately ahead of Titanic and alerted the bridge. First Officer William Murdoch ordered the ship to be steered around the obstacle and the engines to be put in reverse, but it was too late; the starboard side of Titanic struck the iceberg, creating a series of holes below the waterline. Five of the ship's watertight compartments were breached. It soon became clear that the ship was doomed, as she could not survive more than four compartments being flooded. Titanic began sinking bow-first, with water spilling from compartment to compartment as her angle in the water became steeper.

Those aboard Titanic were ill-prepared for such an emergency. The ship's lifeboats had only enough space to carry about half of those on board; if the ship had carried her full complement of about 3,339 passengers and crew, only about a third could have been accommodated in the lifeboats. The crew had not been trained adequately in carrying out an evacuation. The officers did not know how many they could safely put aboard the lifeboats and launched many of them barely half-full. Third-class passengers were largely left to fend for themselves, causing many of them to become trapped below decks as the ship filled with water. The "women and children first" protocol was generally followed for the loading of the lifeboats and most of the male passengers and crew were left aboard.
Two hours and forty minutes after Titanic struck the iceberg, her rate of sinking suddenly increased as her forward deck dipped underwater and the sea poured in through open hatches and grates. As her unsupported stern rose out of the water, exposing the propellers, the ship split apart between the third and fourth funnels due to the immense strain on the keel. The stern remained afloat for a few minutes longer, rising to a nearly vertical angle with hundreds of people still clinging to it At 2:20 am, she sank, breaking loose from the bow section. The remaining passengers and crew were plunged into lethally cold water with a temperature of only 28 °F (−2 °C). Almost all of those in the water died of hypothermia, cardiac arrest, or drowning within minutes. Only 13 of them were helped into the lifeboats though these had room for almost 500 more occupants.
Distress signals were sent by wireless, rockets and lamp, but none of the ships that responded were near enough to reach her before she sank.A nearby ship, the Californian, which was the last to have been in contact with her before the collision, saw her flares but failed to assist. Around 4 am, RMS Carpathia arrived on the scene in response to Titanic's earlier distress calls. 710 people survived the disaster and were conveyed by Carpathia to New York, Titanic's original destination, while 1,514 people lost their lives.